Wednesday, 16 December 2015, 15:00
Sala Grande Palazzina B via alla Cascata 56/C
Raman spectroscopy of biomaterials
1Ceramic Physics Laboratory, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki, 606-8126 Kyoto, Japan,
2Department of Orthopedic Research, Department of Orthopaedics, Loma Linda University, 11406 Loma Linda Drive, Suite 606 Loma Linda, California 92354,
3The Center for Advanced Medical Engineering and Informatics, Osaka University, Yamadaoka, Suita, 565-0871 Osaka, Japan,
4Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, 465 Kajii-cho, Kawaramachi dori, 602-0841 Kyoto, Japan
Raman spectroscopy possesses enormous potentiality for unfolding basic and applicative issues in biomaterials science with both large economic benefits and promising developments into preventive healthcare. However, the physics underlying the Raman effect represents an issue of deep complexity and, in a yet conspicuous lack of working algorithms, its applicative development to biomaterial structures can be considered in its infancy. This lecture starts from basic issues with revisiting some applicative aspects of the physics governing the Raman emission in both synthetic and natural biomaterials. The main aim of the talk is to explore the possibility of disentangling the convoluted dependences of Raman spectra on crystal orientation, chemical and stoichiometric alterations, and mechanical stress. In the second part of the review, systematic characterizations of biomaterials and biomedical devices are presented as explicit applications of the developed equations according to a unified formalism. From a more general perspective, this lecture aims at providing rigorous spectroscopic foundations and working pathways to the analysis of healthy and diseased biogenic tissues, and to the rationalization of both functional behavior and structural reliability of the synthetic components of biomedical devices.
Keywords: Raman spectroscopy, Raman selection rules, secular equations, orientation distribution function, synthetic biomaterials, natural biomaterials.